In a previous paper (part 1) we have developed a new technique, Digital Image Ratio (DIR), which theoretically avoids some of the drawbacks of quantitative digital subtraction radiography. DIR allows the direct computation and visualization of bone-mass-ratio changes. This second part describes the use of DIR analysis to examine 20 sites in 8 patients undergoing regenerative periodontal therapy. Standardized reproducible radiographs of these 20 sites were taken before and 12 months after surgery. Ten experimental sites were treated with bone graft substitutes (Natural Coral or Natural Coral + Collagen), and ten control sites by debridement alone. None of the experimental sites had a density ratio below 1, where 1 indicates no change. The error was 0.07 (0.93 - 1.07). The experimental sites showed an 18% mean increase in bone density (1.18), which increased to 23% (1.23) for sites filled with natural coral alone. All the control sites had values close to 1.00 (1.00 0.07) except for three sites, which showed a 9-15% loss of bone density. It is thus possible to compare and quantify the changes in experimental and control sites in the same patient using the percentage gain or loss of bone density. This demonstrates that DIR is suitable for clinical applications, and can be used in clinical analysis when bone changes are expected.

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